EUDRAGIT L30 D55 PDF

EUDRAGIT L30 D55 PDF

Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.

Author: Mikataxe Togami
Country: Saint Lucia
Language: English (Spanish)
Genre: Technology
Published (Last): 28 April 2006
Pages: 89
PDF File Size: 5.81 Mb
ePub File Size: 2.72 Mb
ISBN: 470-5-90443-117-3
Downloads: 90972
Price: Free* [*Free Regsitration Required]
Uploader: Kekus

We appreciate your input.

Please read our License Agreement regarding materials data and our Privacy Policy. Acrylates Copolymer Information provided by Evonik. All the reagents and solvents used were of analytical grades.

There was a problem providing the content you requested

In vitro release of sod PAS from coated pellets with different weight gain. We also ask that you refer to MatWeb’s terms of use regarding this information. Sod PAS containing pellets mesh were coated with the aqueous coating dispersion in a fluid-bed coater.

Microcrystalline cellulose PH has been found to be an effective diluent in extrusion spheronization. Or if you don’t have an account with us yet, then click here to register. Glcerylmonostearate dispersion in methylene chloride was used for this purpose and was prepared by adding the powder euragit the solvent.

Coating was applied by fluidized bed coater under parameters listed in Table 2.

The enteric polymer, Eudragit L30 D 55 is anionic copolymer contained free carboxylic groups in ratio of 1: Process conditions and parameters used for preparation of g batch of optimized pellets. MatWeb is intended for personal, non-commercial use. Coating was performed in fluidized bed coater under conditions as listed in Table 2. Processing parameters are given in Table 1. Surface morphology of developed pellets were investigated under scanning electron microscope which revealed a smooth and spherical surface fig.

  BERNI RULA PDF

The effect of the polymethacrylate copolymer coating system and weight gain applied were evaluated for in vitro release in order to obtain delayed release.

The total out put of extrudate is mainly governed by the extrusion speed. The multiparticulate formulation of sodium para aminosalicylate for oral administration was developed by extrusion spheronization technique. The carboxylic groups ionize in aqueous media at pH 5. The focus of the present study was to produce pellets as multi-particulate delivery system, because of its advantages over monolithic dosage forms.

The dry ingredients were combined and mixed in twin-shell blender for 20 min and then transferred to planetary mixture where the aqueous binder solution prepared with HPMC E5, was slowly added.

The cumulative percent drug release-time profiles were determined. Ten percent aqueous solution of PEG 8.

e55 Poly methacrylic acid-co-ethyl acrylate 1: Hence it was decided to give a seal coat to protect the drug. Size of the pellets was determined by sieve shaker analysis. At lower speed rpm dumbbell shaped and irregular pellets were observed.

The results indicated that it is euragit to prevent the acidic degradation of sod PAS in upper GI tract which ultimately affect the bioavailability of drug v55 will help to reduce the dose, by development of multiparticulate system coated with pH dependent polymers using extrusion spheronization technique and fluidized bed processor. Acrylates Copolymer Information provided by Evonik Vendors: The pellets were fluidized for 15 min. Pellets were then transferred from the fluidized bed and the residual powder was removed prior to recording the final weight.

The fluid bed coating is currently a widely used technique because it allows, among the other applications, crystals or granules to be coated with a variety of available polymers to provide gastroresistant or controlled release system. It was seen that the drug release from the coated pellets depended on the pH of the dissolution medium as well as weights applied. An over coat was added to Sod D5 pellets that were coated with Eudragit L 30 D to prevent the sticking of the pellets during dissolution studies and storage.

  ENDECOTTS SIEVES PDF

Different weight gains of acrylic polymer were applied onto the pellets and evaluated for in vitro dissolution behavior in 0. d5

EUDRAGIT® L 30 D Spray Suspension Formulation

The friability of the uncoated pellets was determined by euragit 20 g sample of pellets inside a fluidized bed unit fitted with a Wurster insert. The particles were vacuumed, dried and coated with gold palladium and observed microscopically. Bulk density was calculated as the quotient of the weight and volume of pellets.

Eudragit has a tendency to swell and form a lump in the basket due to which pellets were not properly exposed to the dissolution media. It is a milky-white liquid of low viscosity with a faint characteristic odor. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below.

Therefore eudgagit coating solution was sprayed on to the pellets, it solubilized the drug and pulled it into the film as a result of which correct dissolution profile eudrahit not obtained. Property Data This page displays only the text of a material data sheet. On the basis of physical properties and dissolution behavior formulation F4 was taken as optimized formulation. The aim of this study was to develop an enteric ehdragit multiparticulate formulation, which ensures the protection of sod PAS in acidic environment and delivers the drug in intestinal region.