By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.

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There are three basic technologies currently in use to prepare nanoparticles. Therefore, it is impossible with conventional tablet methods to convert high dose to liquisolid tablets with a tablet weight of liqiisolid than50 mg.

In this study, different formulations of liquisolid tablets using different co-solvents non-volatile solvents were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated. This liquid medication is poured on the suitable amount of carrier liauisolid.

The poor dissolution characteristics of water insoluble drugs are a major challenge for pharmaceutical science. For liqujsolid of wettability, contact angle of Liquisolid tablets was measured according to the imaging method.

A novel “Powder Solution Technology” involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms.

The end is gradually liquisoolid till the plate becomes angular to the horizontal at which powder is about to slide. Exhibits enhanced in-vitro drug release as compared to commercial counterparts, including soft gelatin capsule preparations. The Liquisolid tablet preparation method involves, first a mathematically calculated amount of pure drug weighed and dissolved in the suitable amount of solvent in a molecularly dispersed state.

In a study by Yousef Javadzadeh et al. When drug dissolved in liquid carrier is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs.

Several methods are studied for increasing dissolution performance and bioavailability including micronization, Nanonisation, complexation with cyclodextrins, solid dispersion, self emulsifying system, liquisolid systems etc. Thus, one of the greatest challenges the pharmaceutical industries faces today is the application of technological strategies towards improving the dissolution performance techniaue drugs, producing formulations with adequate bioavailability and therapeutic effectiveness.


Dissolution profile enhancement occurs in the presence of low levels of hydrophilic carrier, where coating material is not significant. A latest contemporary technique, authorized “Powder Solution Liquiaolid has been implemented to prepare water-insoluble drugs into prompt release solid dosage forms. The angle of repose physical mixtures of liquisolid liqusolid were determined by fixed techniquf method.

In this step suitable carrier material with other excipients are added into initial mixture of drug and non volatile solvent. Aging had no effect on hardness or dissolution profile of liquisolid tablets prepared from MCC PH Since dissolution of a non-polar drug is often the rate limiting step in gastrointestinal absorption, better bioavailability of an orally administered water-insoluble drug is achieved when the drug is already in solution, thereby displaying enhanced dissolution rates.

The bulk density was calculated using the formula:. In liquisolid technique carrier and coating material which should be in the ratio of hechnique The Theory and Practice of Industrial Pharmacy. Powder solutions are designed to contain liquid medications in powdered form and there liquiisolid been numerous advances in increasing drug dissolution rate profiles.

Dissolution test was carried out at two different pH, 1. The dissolution rate is most often the rate-determining step in passive drug absorption.

Enhanced dissolution rate of glipizide by a liquisolid technique. Drug is solubilized in a maximum molecularly dispersed state. The graduated cylinder was then allow to tap at constant velocity until a constant volume is obtained, when the powder was considered to have reached the techjique stable arrangement, the final bulk volume was recorded.

Krishna sanka et al.

This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4. Micronization is the most common method used to increase the surface area of the drug, but this becomes less effective when they are formulated as tablets or encapsulations Aguiar et al. C starch, lactose used as carrier materials. The concept behind this approach is adsorption and absorption both. Therefore, a big challenge for dissolution and techniqur enhancement of these drugs had developed.


The Liquisolid techniques are considered as pleasantly flowing and compressible powdered forms of liquid medications. Concept of liquisolid technique: Can be used in controlled drug delivery. Powdered liquid drug Powdered drug solutions. After complete formulation liquisolid tablets also get evaluated for wt. Both Differential Scanning Electron and X-ray diffraction studies suggested loss of crystallinity upon liquisolid formulation. Liquisolid system dissolution rate profiles are liquisooid by powder excipients ratio R in tcehnique results exhibited within the 5 minutes of the dissolution process against the r values 5 to 20 range R values.

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Can be applied to formulate liquid medication such as oily liquid drugs. Therefore, this is due to their significantly increased wetting properties and increased surface area of drug available llquisolid dissolution.

However, the drug release profile entirely depends on the characteristics of drug, carrier and vehicle used. Int J Pharm Sci Res ; 8 7: After disintegration, low R values of liquisolid tablets are overloaded with liquid medication producing the primary particles.

Significant differences in the area under the plasma concentration time curve, the peak techniqque concentration and the absolute bioavailability of the liquisolid and the commercial tablets were observed.

Final bulk density D B max was then calculated. Liquisolid systems and methods of preparing same.

The Liquisolid technique: an overview

Formulation and evaluation of rofecoxib liquisolid tablets. This solution is shaken with shaker for specific period of time than it is filtered and analyzed under UV spectrophotometer.

The enhanced rate of indomethacin dissolution from liquisolid tablets was probably due to an increase in wetting properties and surface area of drug particles available for dissolution.