Intrarenal control of renal function is by tubuloglomerular feedback and by glomerulotubular balance. In tubu- loglomerular feedback, Na/Cl delivery to the. Tubuloglomerular feedback is an adaptive mechanism that links the rate of glomerular . Intrinsic—Tubuloglomerular Feedback and Glomerulotubular Balance. Glomerulotubular Balance refers to the phenomenon whereby a constant layer of protection if mechanisms of tubuloglomerular feedback, that normalize rates.

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Glomerulotubular balance ties peritubular capillary filtrate reabsorption to glomerular filtration rate. This page was last edited on 16 Decemberat Overview Glomerulotubular Balance refers to the phenomenon whereby a constant fraction of the filtered load of the nephron is resorbed across a range of Glomerular Filtration Rates GFR.

Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis.

In other words, if the GFR spontaneously increases, the rate of water and solute resorption in the tubule proportionally increases, thus maintaining the same fraction the filtered load being resorbed. Tubuloglomerular feedback is one of several mechanisms the tubulkglomerular uses to regulate glomerular filtration rate GFR. The Mechanisms of Body Function.

Consequently, the regulation of GFR also results in the autoregulation of renal blood flow. Secretion clearance Pharmacokinetics Clearance of medications Urine flow rate.


Baroreflex Kinin—kallikrein system Renin—angiotensin system Vasoconstrictors Vasodilators Autoregulation Myogenic mechanism Tubuloglomerular feedback Cerebral autoregulation Paraganglia Aortic body Carotid body Glomus cell. The increased load on the kidney of high-protein diet is a result of an increase in reabsorption of NaC.

Tubuloglomerular feedback – Wikipedia

The mechanistic basis of glomerulotubular balance is poorly understood but appears to act completely independently of neuroendocrine regulatory tubuloglomeurlar and is likely an intrinsic property of the nephron itself. As the TAL ascends through the renal cortex, it encounters its own glomerulusbringing the macula densa to rest at the angle between the afferent and efferent arterioles.

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Tubuloglomerular feedback results in the regulation of GFR. Intrarenal control of renal function is by tubuloglomerular feedback and by glomerulotubular balance. Annual Review of Physiology. The muscle tension in the afferent arteriole is modified based on the difference between the sensed concentration and a target concentration. Excluding loop diuretic use, the usual situation that causes a reduction in reabsorption of NaCl via the NKCC2 at the macula densa is a low tubular lumen concentration of NaCl.

Fluid balance Darrow Yannet diagram Body water: Glomerulotubular balance can be thought of as an additional layer of protection if mechanisms of tubuloglomerular feedbackthat normalize rates of GFR, momentarily fail or are slow to be triggered.


The macula densa’s detection of elevated sodium chloride concentration in the tubular lumen, which leads to a decrease in GFR, is based on the concept of purinergic signaling.

A drop in arterial blood pressure causes both a decrease in GFR and a decrease in renal blood flow. The threshold at which the loop of Henle flow rate initiates feedback responses is affected.

The afferent arteriole dilates, which increases glomerular capillary pressure. Thus, TGF-induced vasoconstriction is usually limited in magnitude. Skip to main content.

American Journal of Physiology. Physiology of the kidneys and acid-base physiology. Physiology of the cardiovascular system. An increase in filtration at the glomerulus enhances filtrate reabsorption at the peritubular capillaries.

From Wikipedia, the free encyclopedia. Saunders, An Imprint of Elsevier. The macula densa uses the composition of the tubular fluid as an indicator tubuloglomerulag GFR. The size of the TGF response is directly dependent upon these changes. Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction. A Cellular And Molecular Approach. Efferent arteriolar constriction increases glomerular capillary pressure.